CJC-1295 No-DAC (Modified GRF 1-29) is a 29-residue GHRH analog with four amino acid substitutions that resist enzymatic degradation, studied for its stimulation of endogenous growth hormone release. Supplied as a ≥99% HPLC-verified lyophilized powder for laboratory research use only.
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Third-Party Tested by Janoshik Analytical
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Compound Information
Technical specifications
Lyophilized powder; keep sealed, dry, and protected from light
Store at a stable temperature; minimize warming/cooling cycles
Aliquot after reconstitution; avoid repeated freeze–thaw cycles
Lyophilized Powder
-20°C preferred; 2–8°C for short-term handling
Reconstituted
2–8°C
CJC-1295 No-DAC, also known as Modified GRF (1–29), is a synthetic analog of the biologically active fragment of growth hormone-releasing hormone. It carries four amino acid substitutions relative to native GRF, each chosen to resist a specific degradation pathway — most notably a D-alanine at position 2 that blocks DPP-4 cleavage. Unlike the DAC variant, this version lacks the Drug Affinity Complex that binds serum albumin, so its half-life is measured in minutes rather than days. That short window is the point: it produces a sharp, discrete pulse of GH release, making it the preferred variant for studies where preserving natural pulsatile secretion patterns matters. Supplied as a high-purity lyophilized powder for reproducible in-vitro and approved in-vivo work. This product is for laboratory research and development purposes only and must be handled by qualified professionals. Not for human, therapeutic, or diagnostic use.
Pulsatile GH Release
Its short half-life produces a discrete GH pulse rather than sustained elevation — preserving natural secretion patterns in study models.
Four Stabilizing Substitutions
Each substitution targets a distinct degradation pathway, with D-Ala at position 2 blocking DPP-4 cleavage specifically.
No Albumin Binding
Without the Drug Affinity Complex, clearance is rapid — giving researchers tight temporal control over the stimulus window.
GH–IGF-1 Axis Studies
A standard reference compound for investigating downstream IGF-1 signaling and hepatic response to GH stimulation.
Endogenous Secretagogue
Acts upstream at the pituitary to stimulate the body’s own GH output, rather than supplying exogenous hormone.
≥99% HPLC Purity
Every batch is HPLC-verified and supplied lyophilized, ensuring reproducible results across long study timelines.
