TB-500 is a synthetic peptide corresponding to the actin-binding domain of thymosin beta-4, studied for its role in actin sequestration, cell migration, and angiogenic signaling. Supplied as a ≥99% HPLC-verified lyophilized powder for laboratory research use only.
€ 49.99
34 in stock
Third-Party Tested by Janoshik Analytical
Compound Information
Technical specifications
Lyophilized powder; keep sealed, dry, and protected from light
N-terminal acetylation improves stability relative to the free-amine form
Aliquot after reconstitution; avoid repeated freeze–thaw cycles
Lyophilized Powder
-20°C preferred; 2–8°C for short-term handling
Reconstituted
2–8°C
TB-500 is a synthetic seven-residue peptide corresponding to the actin-binding domain of thymosin beta-4 (Tβ4), a naturally occurring 43-residue protein found in most mammalian cells. The full-length protein’s principal function is sequestering monomeric G-actin, regulating the pool available for polymerization into filaments — and that activity localizes to the LKKTETQ motif reproduced here. Isolating this fragment gives researchers a compact, stable tool for probing actin dynamics without the handling demands of the full protein. TB-500 is investigated for its influence on cell migration, cytoskeletal remodeling, and angiogenic signaling, and is frequently used in wound-repair and tissue-regeneration models. Supplied as a high-purity lyophilized powder for reproducible in-vitro and approved in-vivo work. This product is for laboratory research and development purposes only and must be handled by qualified professionals. Not for human, therapeutic, or diagnostic use.
Actin Sequestration
Reproduces the LKKTETQ motif responsible for Tβ4’s binding of monomeric G-actin, regulating the polymerization pool.
Cell Migration
Widely used in scratch and transwell assays examining cytoskeletal remodeling and directional cell motility.
Angiogenic Signaling
Investigated for its influence on endothelial cell behavior and vascular network formation in tissue models.
Compact Alternative to Tβ4
A seven-residue peptide is far simpler to handle, dissolve, and dose than the full 43-residue parent protein.
Acetylated N-Terminus
The acetyl cap improves stability against aminopeptidase cleavage relative to the free-amine form.
≥99% HPLC Purity
Every batch is HPLC-verified and supplied lyophilized, ensuring reproducible results across long study timelines.
