IGF-1 LR3 is a 83-residue analog of insulin-like growth factor 1, modified with an Arg³ substitution and a 13-residue N-terminal extension that sharply reduce IGFBP binding. Supplied as a ≥95% HPLC-verified lyophilized powder for laboratory research use only.
€ 64.99
Out of stock
Third-Party Tested by Janoshik Analytical
Compound Information
Technical specifications
Lyophilized powder; keep sealed, dry, and protected from light
A folded protein — more sensitive to heat and agitation than short peptides
Three disulfide bridges — avoid reducing agents in the working buffer
Lyophilized Powder
-20°C preferred; 2–8°C for short-term handling
Reconstituted
2–8°C; aliquot and avoid freeze–thaw
IGF-1 LR3 (Long R3 IGF-1) is a recombinant analog of insulin-like growth factor 1, carrying two engineered changes: an arginine substitution at position 3, and a 13-residue extension on the N-terminus. Both modifications serve the same purpose — sharply reducing the protein’s affinity for IGF-binding proteins (IGFBPs), which in native IGF-1 sequester the vast majority of circulating hormone. The result is an analog that remains available to engage the IGF-1 receptor rather than being bound up in complex. This makes LR3 a widely used tool in cell culture, where it is a standard supplement in serum-free media, and in studies of IGF-1R signaling, PI3K/Akt pathway activation, and cellular proliferation. Supplied as a high-purity lyophilized powder. This product is for laboratory research and development purposes only and must be handled by qualified professionals. Not for human, therapeutic, or diagnostic use.
Reduced IGFBP Binding
Both the Arg³ substitution and the N-terminal extension sharply lower affinity for binding proteins that sequester native IGF-1.
Cell Culture Standard
A common supplement in serum-free and reduced-serum media, where its BP-resistance makes it more reliably active than native IGF-1.
PI3K/Akt Pathway Studies
Engages IGF-1R to activate the PI3K/Akt cascade — a central axis in proliferation, survival, and protein synthesis research.
Cellular Proliferation
Widely used to drive growth and division in cultured cell lines, including myoblast and fibroblast models.
Recombinant Protein
Unlike the short peptides in this catalog, LR3 is a folded 83-residue protein with three disulfide bridges — handle accordingly.
≥95% HPLC Purity
Every batch is HPLC-verified and supplied lyophilized, ensuring reproducible activity across long study timelines.
