MOTS-c is a 16-residue mitochondrial-derived peptide encoded in the mtDNA 12S rRNA region, studied for its role in AMPK activation, metabolic homeostasis, and mitochondrial–nuclear signaling. Supplied as a ≥98% HPLC-verified lyophilized powder for laboratory research use only.
Price range: € 39.99 through € 99.99
Third-Party Tested by Janoshik Analytical
Compound Information
Technical specifications
Lyophilized powder; keep sealed, dry, and protected from light
Contains methionine residues — minimize exposure to air and oxidants
Aliquot after reconstitution; avoid repeated freeze–thaw cycles
Lyophilized Powder
-20°C preferred; 2–8°C for short-term handling
Reconstituted
2–8°C
MOTS-c (Mitochondrial ORF of the 12S rRNA type-c) is a 16-residue peptide encoded not in nuclear DNA but within the mitochondrial genome itself — making it one of a small class of mitochondrial-derived peptides (MDPs). Its discovery challenged the long-held view that mitochondria signal only through metabolites, and it is now studied as a retrograde signal: a molecule that travels from mitochondrion to nucleus to influence gene expression. Research centers on its activation of the AMPK pathway, its role in folate–methionine cycle regulation, and its influence on glucose handling and metabolic homeostasis, particularly in skeletal muscle. Supplied as a high-purity lyophilized powder for reproducible in-vitro and approved in-vivo work. This product is for laboratory research and development purposes only and must be handled by qualified professionals. Not for human, therapeutic, or diagnostic use.
Mitochondrial-Derived Peptide
Encoded in mtDNA rather than nuclear DNA — a member of a small, still-emerging class of signaling molecules.
AMPK Pathway Activation
Studied for its engagement of AMP-activated protein kinase, placing it alongside compounds like AICAR in metabolic research.
Retrograde Nuclear Signaling
Investigated for its translocation to the nucleus and influence on stress-responsive gene expression.
Glucose Handling
Widely referenced in skeletal muscle models examining insulin sensitivity and glucose utilization.
Folate–Methionine Cycle
Its proposed mechanism runs through one-carbon metabolism, connecting mitochondrial output to cellular methylation state.
≥98% HPLC Purity
Every batch is HPLC-verified and supplied lyophilized, ensuring reproducible results across long study timelines.
