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Tesamorelin

Tesamorelin

Tesamorelin is a stabilized 44-residue GHRH analog with an N-terminal trans-3-hexenoyl modification that resists DPP-4 degradation, studied for its stimulation of endogenous growth hormone release. Supplied as a ≥98% HPLC-verified lyophilized powder for laboratory research use only.

+99% Purity Third-Party Tested COA Available

Price range: € 59.99 through € 99.99

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Certificate of Analysis

Third-Party Tested by Janoshik Analytical

Latest
99.372%
Purity
Variant
10mg
Lot #
TES10-2605
Labeled
Tesamorelin 10 mg
Actual
N/A
Tested
View Certificate
Latest
98.572%
Purity
Variant
20mg
Lot #
TSM202607
Labeled
Tesamorelin
Actual
N/A
Tested
Jun 24, 2026
View Certificate

Compound Information

Technical specifications

Molecular Profile

What Is Tesamorelin?

TypeGHRH Analog (Growth Hormone Secretagogue)
CAS Number218949-48-5
Molecular Weight5135.83 g/mol
SynonymsTH9507 / Egrifta / Trans-3-hexenoyl-GHRH(1–44)
Amino Acids44 AA (N-terminal trans-3-hexenoyl group)
SequenceTrans-3-hexenoyl-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2
FormulaC221H366N72O67S
Storage Requirements

Stability Information

Lyophilized powder; keep sealed, dry, and protected from light
Store at a stable temperature; minimize warming/cooling cycles
Aliquot after reconstitution; avoid repeated freeze–thaw cycles

Lyophilized Powder

-20°C preferred; 2–8°C for short-term handling

Reconstituted

2–8°C

About Tesamorelin

Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH), consisting of the full 44-residue human GHRH sequence with a trans-3-hexenoyl group attached at the N-terminus. This modification substantially slows degradation by dipeptidyl peptidase-4 (DPP-4), giving the peptide a longer functional half-life than native GHRH. It acts on pituitary GHRH receptors to stimulate endogenous growth hormone release, making it a reference compound for studying the GHRH–GH–IGF-1 axis, pulsatile secretion dynamics, and visceral adipose signaling. Supplied as a high-purity lyophilized powder for reproducible in-vitro and approved in-vivo work. This product is for laboratory research and development purposes only and must be handled by qualified professionals. Not for human, therapeutic, or diagnostic use.

Research Highlights

Endogenous GH Release

Acts on pituitary GHRH receptors to stimulate the body’s own growth hormone output rather than supplying exogenous GH.

DPP-4 Resistance

The N-terminal trans-3-hexenoyl modification slows enzymatic cleavage, extending functional half-life relative to native GHRH.

GH–IGF-1 Axis Studies

A standard reference compound for investigating downstream IGF-1 signaling and hepatic response to GH stimulation.

Visceral Adipose Research

Widely referenced in preclinical models examining lipolytic signaling and visceral fat distribution.

Pulsatile Secretion Dynamics

Because it works upstream at the pituitary, it preserves the natural pulsatile pattern of GH release in study models.

≥98% HPLC Purity

Every batch is HPLC-verified and supplied lyophilized, ensuring reproducible results across long study timelines.

Product Specifications

Molecular Formula
C221H366N72O67S
Molecular Weight
5135.83 g/mol
CAS Number
218949-48-5
Sequence
Trans-3-hexenoyl-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2
Purity
≥98% (HPLC verified)
Form
Lyophilized powder
Appearance
White to off-white powder
Solubility
Soluble in water, bacteriostatic water
Storage
-20°C (lyophilized), 2–8°C (reconstituted)

Research Studies

Frequently Asked Questions

What is Tesamorelin?

Tesamorelin is a synthetic 44-residue analog of growth hormone-releasing hormone (GHRH), modified at the N-terminus with a trans-3-hexenoyl group to resist enzymatic degradation.

How does it differ from native GHRH?

The N-terminal modification slows cleavage by DPP-4, giving Tesamorelin a longer functional half-life than unmodified GHRH while retaining receptor activity.

Why is it used in growth hormone research?

Because it acts upstream at the pituitary rather than supplying exogenous hormone, it allows researchers to study endogenous GH release, pulsatile secretion patterns, and downstream IGF-1 signaling.

Is this product approved for human use?

No. This product has not been evaluated by the FDA and is strictly intended for research and development purposes by qualified professionals only.

Tesamorelin molecular structure

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