Semax is a synthetic heptapeptide combining the ACTH(4–7) fragment with a C-terminal Pro-Gly-Pro extension, studied for its influence on BDNF expression and neurotrophic signaling without corticotropic activity. Supplied as a ≥99% HPLC-verified lyophilized powder for laboratory research use only.
€ 29.99
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Third-Party Tested by Janoshik Analytical
Compound Information
Technical specifications
Lyophilized powder; keep sealed, dry, and protected from light
Pro-Gly-Pro terminus confers resistance to enzymatic cleavage
Aliquot after reconstitution; avoid repeated freeze–thaw cycles
Lyophilized Powder
-20°C preferred; 2–8°C for short-term handling
Reconstituted
2–8°C
Semax is a synthetic heptapeptide built from the ACTH(4–7) fragment (Met-Glu-His-Phe) with a C-terminal Pro-Gly-Pro extension. The extension serves two purposes: it markedly slows enzymatic degradation compared to the bare fragment, and it removes the corticotropic activity of full-length ACTH — allowing researchers to study the peptide’s neurotropic effects in isolation from adrenal signaling. Semax is investigated primarily for its reported influence on BDNF and NGF expression, dopaminergic and serotonergic modulation, and neuroprotection in cerebral ischemia models. Much of the foundational work originates from Russian research groups. Supplied as a high-purity lyophilized powder for reproducible in-vitro and approved in-vivo work. This product is for laboratory research and development purposes only and must be handled by qualified professionals. Not for human, therapeutic, or diagnostic use.
BDNF & NGF Expression
Most commonly studied for its reported upregulation of neurotrophic factors in hippocampal and cortical tissue models.
No Corticotropic Activity
Unlike full-length ACTH, Semax does not stimulate adrenal signaling — isolating neurotropic effects from HPA-axis confounds.
Enzymatic Stability
The C-terminal Pro-Gly-Pro extension substantially slows proteolytic cleavage relative to the bare ACTH(4–7) fragment.
Neurotransmitter Modulation
Investigated for its influence on dopaminergic and serotonergic signaling in preclinical CNS models.
Cerebral Ischemia Models
A frequently referenced compound in preclinical neuroprotection studies examining response to reduced cerebral perfusion.
≥99% HPLC Purity
Every batch is HPLC-verified and supplied lyophilized, ensuring reproducible results across long study timelines.
