PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide analog of α-MSH that acts as a melanocortin receptor agonist, studied primarily for MC4R-mediated signaling in the central nervous system. Supplied as a ≥99% HPLC-verified lyophilized powder for laboratory research use only.
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Third-Party Tested by Janoshik Analytical
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Compound Information
Technical specifications
Lyophilized powder; keep sealed, dry, and protected from light
Cyclic structure confers good stability relative to linear analogs
Aliquot after reconstitution; avoid repeated freeze–thaw cycles
Lyophilized Powder
-20°C preferred; 2–8°C for short-term handling
Reconstituted
2–8°C
PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH), structurally derived from Melanotan II. Its cyclic lactam architecture confers greater metabolic stability than linear melanocortin peptides while preserving receptor affinity. It acts as an agonist across several melanocortin receptor subtypes, with research interest centered on MC4R and MC3R signaling in the central nervous system. This makes PT-141 a reference compound for investigating melanocortin pathway activation, receptor-subtype selectivity, and downstream neural signaling. Supplied as a high-purity lyophilized powder for reproducible in-vitro and approved in-vivo work. This product is for laboratory research and development purposes only and must be handled by qualified professionals. Not for human, therapeutic, or diagnostic use.
Melanocortin Receptor Agonism
Engages multiple melanocortin receptor subtypes, making it a useful probe for mapping pathway activation across the family.
MC4R Signaling Studies
Research interest centers on MC4R engagement in the central nervous system and its downstream neural signaling effects.
Cyclic Lactam Stability
The constrained ring structure resists enzymatic degradation better than linear analogs while retaining receptor affinity.
Receptor-Subtype Selectivity
Its cross-subtype activity makes it a common comparator in binding assays that characterize newer, more selective ligands.
Structural Analog Reference
Derived from Melanotan II, giving researchers a defined structural point of comparison within the melanocortin peptide family.
≥99% HPLC Purity
Every batch is HPLC-verified and supplied lyophilized, ensuring reproducible results across long study timelines.
