€ 39.99
38 in stock
Third-Party Tested by Janoshik Analytical
Compound Information
Technical specifications
Lyophilized powder form for maximum stability
White to off-white crystalline appearance
Protect from direct light, moisture, and heat
Lyophilized Powder
-20°C preferred; 2–8°C for short-term handling
Reconstituted
2–8°C
AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a laboratory-grade nucleoside analog widely studied as a direct activator of AMP-activated protein kinase (AMPK). Once inside the cell, AICAR is phosphorylated to ZMP, an AMP mimetic that engages the AMPK signaling cascade without altering cellular ATP levels. This makes it a valuable reference compound for researchers investigating metabolic regulation, glucose uptake, fatty acid oxidation, and mitochondrial biogenesis. Supplied as a high-purity lyophilized powder in a 50mg vial, AICAR delivers consistent, reproducible results for in-vitro and in-vivo studies of cellular energy homeostasis and endurance-related metabolic pathways.
Direct AMPK Activation
Phosphorylated intracellularly to ZMP, an AMP mimetic that engages AMPK without depleting cellular ATP — a clean tool for isolating AMPK-dependent effects.
Glucose Uptake Studies
Widely referenced in models exploring GLUT4 translocation and insulin-independent glucose transport in skeletal muscle tissue.
Mitochondrial Biogenesis
Investigated for PGC-1α upregulation and its downstream role in oxidative capacity and mitochondrial density.
Fatty Acid Oxidation
Studied for its inhibition of acetyl-CoA carboxylase and the resulting shift toward lipid substrate utilization.
Endurance & Energy Homeostasis
A standard reference compound in preclinical models of exercise mimetics and cellular energy-sensing pathways.
≥99% HPLC Purity
Every batch is HPLC-verified and supplied lyophilized for maximum stability, ensuring reproducible in-vitro and in-vivo results.
